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Welcome to the University of Iowa atypical HUS Center of Excellence

The University of Iowa founded in 1847, is a major national research university with a current enrollment of about 30,000 students and a total of approximately 2,700 faculty. The University is one of three regent universities operated by the State of Iowa, a state widely renowned for supporting the highest quality of education for its population.

The Carver College of Medicine at the University of Iowa was established in 1879, is the only allopathic medical school in the state. It is a major component of the University of Iowa health sciences center, which also includes the Colleges of Dentistry, Nursing, Pharmacy and Public Health, University of Iowa Hospitals and Clinics, the University Hygienic Laboratory, and the Iowa City Veterans Affairs Medical Center. The tripartite mission of the College includes the education of students, the care of patients, and the commitment to understanding basic biological processes.

The overarching objective of the University of Iowa Pediatric Nephrology Center of Excellence is to improve the healthcare of patients with atypical Hemolytic Uremic Syndrome (aHUS) and other aHUS-like diseases through a collaborative effort focused on the presentation, rapid diagnosis, underlying genetics and pathophysiology of aHUS.

Atypical HUS (aHUS) is a life-threatening, debilitating microangiopathic hemolytic anemia with thrombocytopenia and renal failure. Presently there are no clear diagnostic criteria and the genetic testing that confirms the diagnosis is not readily available to most clinicians. Children, preferentially affected by aHUS, continue to suffer a high initial mortality rate, as well as have a long-term risk for neurologic and cardiac impairment.  The majority of affected individuals are left with renal impairment and End Stage Renal Disease with recurrence in renal allografts is common.  The healthcare and societal costs are immense. Understanding aHUS is an important national (global) goal.  The University of Iowa Pediatric Nephrology Division and its Molecular Otorhinolaryngology and Renal laboratories (MORL) have recognized national and international expertise in the area of complement-mediated renal diseases, such as aHUS and their partnership in this center proposal is a logical extension of their long-standing collaborative interests.